2006•Dalian Yike Daxue xuebaoRequires access
Expression and significance of survivin protein in prostate cancer
Xue-yan Xia
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Abstract
[Objective] To explore the expression and the clinical significance of survivin proteins in tissues of prostatic carcinoma(PCa).[Methods] The immunohistological staining was used to evaluate the expression of survivin protein in 43 cases of prostatic carcinoma(PCa) and 5 cases of normal prostate(NP).[Results] The positive rate of survivin protein was 81.40%(35/43) in PCa,the rates were 100%,84.62%,57.14% in the low,middle and high differentation prostatic carcinoma groups respectively,the rates were 72.41% and 100% in stage A-B and C-D.Expression of surviving protein in 5 cases of normal prostate(NP) was negative.[Conclusion] Detection of survivin is valuable for making diagnosis,and evaluating malignancy and prognosis of PCa.