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2010•Liaoning zhongyi zazhiRequires access

Determination of Ginsenoside Rg1,Ginsenoside Rb1 and Notoginsenoside R1 in Fufang Xueshuantong Capsules by HPLC

Peng Gao

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Abstract

Objective:To establish a HPLC method for determination of the content of ginsenoside Rg1,ginsenoside Rb1 and notoginsenoside R1 in Fufang xueshuantong Capsules.Methods:The contents of ginsenoside Rb1,ginsenoside Rg1 and notoginsenoside R1 were separated by gradient elution on Shimadzu-C18 column (5μm,4. 6mm×100mm)as stationary phase; acetonitrile and water as gradientmixed mobile phase; detected at 203 nm wavelength;40℃ of column temperature and 1. 0mL/min of mobile rate.Results:Ginsenoside Rb1、ginsenoside Rg1 and notoginsenoside R1 all had good linearities at the range of 0.868～8.680μg(r=0.9999,n=6),0.892～8.920μg(r=1.0000,n=6)and 0.308～3.080μg(r=1.0000,n=6).The Average recovery rates of ginsenoside Rb1、ginsenoside Rg1 and notoginsenoside were 100.11%,RSD 0.71%;99.91%,RSD 0.87%;99.90%,RSD 1.61%,(n=5).Conclusion:The method is accurate and specific.

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Objective:To establish a HPLC method for determination of the content of ginsenoside Rg1,ginsenoside Rb1 and notoginsenoside R1 in Fufang xueshuantong Capsules.Methods:The contents of ginsenoside Rb1,ginsenoside Rg1 and notoginsenoside R1 were separated by gradient elution on Shimadzu-C18 column (5μm,4. 6mm×100mm)as stationary phase; acetonitrile and water as gradientmixed mobile phase; detected at 203 nm wavelength;40℃ of column temperature and 1. 0mL/min of mobile rate.Results:Ginsenoside Rb1、ginsenoside Rg1 and notoginsenoside R1 all had good linearities at the range of 0.868～8.680μg(r=0.9999,n=6),0.892～8.920μg(r=1.0000,n=6)and 0.308～3.080μg(r=1.0000,n=6).The Average recovery rates of ginsenoside Rb1、ginsenoside Rg1 and notoginsenoside were 100.11%,RSD 0.71%;99.91%,RSD 0.87%;99.90%,RSD 1.61%,(n=5).Conclusion:The method is accurate and specific.

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Available abstract

Objective:To establish a HPLC method for determination of the content of ginsenoside Rg1,ginsenoside Rb1 and notoginsenoside R1 in Fufang xueshuantong Capsules.Methods:The contents of ginsenoside Rb1,ginsenoside Rg1 and notoginsenoside R1 were separated by gradient elution on Shimadzu-C18 column (5μm,4. 6mm×100mm)as stationary phase; acetonitrile and water as gradientmixed mobile phase; detected at 203 nm wavelength;40℃ of column temperature and 1. 0mL/min of mobile rate.Results:Ginsenoside Rb1、ginsenoside Rg1 and notoginsenoside R1 all had good linearities at the range of 0.868～8.680μg(r=0.9999,n=6),0.892～8.920μg(r=1.0000,n=6)and 0.308～3.080μg(r=1.0000,n=6).The Average recovery rates of ginsenoside Rb1、ginsenoside Rg1 and notoginsenoside were 100.11%,RSD 0.71%;99.91%,RSD 0.87%;99.90%,RSD 1.61%,(n=5).Conclusion:The method is accurate and specific.

Key concepts: Ginsenoside Rg1, Ginsenoside, Chromatography, Gradient elution, Medicine, High-performance liquid chromatography, Pharmacology, Chemistry

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Determination of Ginsenoside Rg1,Ginsenoside Rb1 and Notoginsenoside R1 in Fufang Xueshuantong Capsules by HPLC — Research Paper | ScholarLens