Protective Effect of Cyclosporin A on Cerebral Ischemia-Reperfusion Injury in Rats

Objective: To explore the protective effect of cyclosporin A on cerebral ischemia-reperfusion injury in rat. Methods: 108 Wistar rats were divided into 3 groups, sham operation group, saline control group and cyclosporin A treatment group. The focal cerebral ischemia-reperfusion injury model was made by suture-occluded method. The score of behavior obstacles of rats were evaluated. The cerebral water content was determined by method of dry-wet weight. TTC staining was used to calculate the cerebra infarct volume. The morphological changes of cerebra were observed under an electron microscope. Results: In the scheduled time, the score of behavior obstacles in cyclosporin A group was higher than in saline group ( P 0.05); both the infarct volume and the cerebral water content in cyclosporin A group were significantly lower than in the saline group ( P 0.05); the electron microscopy showed that the cerebral morphological changes were milder in cyclosporin A group than in saline group; the sham operation group had no obvious abnormal change in each observational item. Conclusion: The immune factors may play an important role in cerebral ischemic reperfusion injury of rats. Cyclosporin A could have protective effects on cerebral ischemic reperfusion injury in rats.