Change an significance of vascular endothelial growth factor level in serum of patients with non-small cell lung cancer

Objective To determine the serum vascular endothelial growth factor(VEGF) level in patients with non-small cell lung cance(NSCLC) and explore its diagnostic value.Methods 32 NSCLS patients,19 patients with lung benign tumor and 30 healthy control subjects were included in this study.Serum VEGF level was measured by sandwith ELISA.Results Serum VEGF level in NSCLC(16.27±2.32 μg/ml) was significantly higher than those of lung benign tumor(11.08±2.02 μg/ml) and those of healthy subjects(10.52±2.03 μg/ml)(P0.001).The serum VEGF level in NSCLC was closely related to P-TNM stages,lymph node metastasis status and cell differentiation grade(P0.001).Using the criterion of serum VEGF level14.58 μg/ml,the sensitivity and specificity of the diagucsis for NSCLC were 71.88% and 93.33%,respectively.Conclusion The level of serum VEGF could be considered as a useful biological indicator to evaluate invasion and metastasis of NSCLC.