Effect of chemotherapeutics and embolization on tumor inhibition and liver injury in TACE treatment of hepatic carcinoma

Objective To discuss the effect of chemotherapeutics and embolization on tumor inhibition and liver injury in TACE treatment of hepatic carcinoma.Methods AFP and liver function were investigated and evaluated in 152 HCC patients who had been treated by TAC(group A,n=30) or TAE(group B,n=29) or TACE(group C,n=93) without extra-liver metastasis.Results At the 1std and 4thd after TACE,(1)the rate of AFP decrease were higher in group B(56.5%,78.3%) and group C(67%,80.7%) than that in group A(25%,25%),P0.01.(2)the abnormal rate amplification,bilirubin total was higher in group A(119.54%,116.1%) and group C(157.8%,140%) than that in group B(41.3%,28%),P0.001.ALT and ALB were higher both in group B and group C than that in group A,P0.005.Pre-albumin was higher in group C(17.5%,114.4%)than that in group A(3.3%,0) and group B(3.5%,29.4%),P0.005.Conclusion It is chemoembolization that play an important role in tumor inhibitory action in TACE treatment.The increase of chemotherapeutics dosage accompanied exacerbation of liver injury.It suggested that the control of best combining site both increase tumor inhibitory action and decrease liver injury is key point to evaluate therapeutic effect of TACE.