Analysis of 150 cases of chorionic villi in the first trimester of pregnancy

Objective To evaluate the feasibility,accuracy and safety of chorionic villus sampling(CVS).Methods The chorionic villi were aspirated per the cervix in blind method.The choromosomes and G band were prepared by direct villi method or short-stage culture method.Results In 150 samples,6 samples were found to have abnormal karyotype.The results from 35 prenatal diagnosis were accordant with those obtained by chromosomal karyotype re-examination in the amniotic fluid,artificial aborted chorionic villi or cord blood.65 neonates were normal in development at follow-up.Conclusion Chorionic villus sampling for prenatal diagnosis is safe and feasible.