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2008•Journal of Clinical HematologyRequires access

Clinical significance of pre-S1 of HBV in several common HBV infection models

Yanlong Yang

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Abstract

Objective:To investigate the clinical significance of pre-S1 of HBV in several common HBV infection models.Method: Pre-S1,HBV-DNA and the serum markers of HBV were measured in 353 HBV patients and 50 controls.Result:The positive rates of pre-S1 and HBV-DNA were 85.7% and 87.8% in the HBsAg(+)、HBeAg(+)、HBcAb(+) model,53.9%and 49.4%in the HBsAg(+)、HBcAb(+)、HBeAb(+)model,78.3%and 80.0%in the HBsAg(+)、HBeAg(+) model,28.6%and 24.5%in the HBsAg(+)、HBcAb(+) model,16.7%and 0.0%in the HBsAg(+)、HBeAg(+)、HBeAb(+) model,0.0%and 0.0% in others.Conclusion: Pre-S1 of HBV may be used as a reliable marker of HBV replication in vivo.

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What this paper is about

Objective:To investigate the clinical significance of pre-S1 of HBV in several common HBV infection models.Method: Pre-S1,HBV-DNA and the serum markers of HBV were measured in 353 HBV patients and 50 controls.Result:The positive rates of pre-S1 and HBV-DNA were 85.7% and 87.8% in the HBsAg(+)、HBeAg(+)、HBcAb(+) model,53.9%and 49.4%in the HBsAg(+)、HBcAb(+)、HBeAb(+)model,78.3%and 80.0%in the HBsAg(+)、HBeAg(+) model,28.6%and 24.5%in the HBsAg(+)、HBcAb(+) model,16.7%and 0.0%in the HBsAg(+)、HBeAg(+)、HBeAb(+) model,0.0%and 0.0% in others.Conclusion: Pre-S1 of HBV may be used as a reliable marker of HBV replication in vivo.

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Available abstract

Objective:To investigate the clinical significance of pre-S1 of HBV in several common HBV infection models.Method: Pre-S1,HBV-DNA and the serum markers of HBV were measured in 353 HBV patients and 50 controls.Result:The positive rates of pre-S1 and HBV-DNA were 85.7% and 87.8% in the HBsAg(+)、HBeAg(+)、HBcAb(+) model,53.9%and 49.4%in the HBsAg(+)、HBcAb(+)、HBeAb(+)model,78.3%and 80.0%in the HBsAg(+)、HBeAg(+) model,28.6%and 24.5%in the HBsAg(+)、HBcAb(+) model,16.7%and 0.0%in the HBsAg(+)、HBeAg(+)、HBeAb(+) model,0.0%and 0.0% in others.Conclusion: Pre-S1 of HBV may be used as a reliable marker of HBV replication in vivo.

Key concepts: HBsAg, HBeAg, Medicine, Hepatitis B virus, Virology, Clinical significance, Immunology, Internal medicine

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