2002•Medical Journal of National Defending Forces in Northwest ChinaRequires access

Effection of polychlorinated biphenyls in cultured hippocampal neuronic cells of rats

Wang Yuhong

Abstract

Objective:To evaluate the effect of Polychlorinated Biphenyls(PCB) in cultured hippocampal neuronic cells of rats.Methods:After rats' hippocampal cells were cultured with different PCB, MTT was used to observe the growth and development of hippocampal cells.Results:It was obvious that hippocampal neuronic cells was inhibited in the highest groups of PCB,10 -4 group was apparently lower than that of control group(P0.01);10 -7 and 10 -6 groups were lower than that of control group(P0.05);The live rate of cell was reduced.Conclusion:PCB had strong nerve toxicity to hippocampal neuronic cells.

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Key concepts: Hippocampal formation, Chemistry, Cell, Internal medicine, Nerve cells, Endocrinology, Andrology, Biology