Effects of different doses of atorvastatin on interleukin-6 and hypersensitive C-reactive protein in patients with unstable angina pectoris

Objective To investigate the effects of different doses of atorvastatin on interleukin-6(IL-6)and hypersensitive C-reactive protein(hs-CRP)in patients with unstable angina pectoris(UAP).Methods 94 patients with UAP were randomly divided into three groups:the patients in control group were given routine therapy,the patients in control treatment group,on the basis of control group,were given atorvastatin 10mg,and the patients in treatment group were given atorvastatin 20mg,besides the conventional therapy.The levels of blood lipids,IL-6,hs-CRP were detected before and after the treatments.Results After treatment,the levels of blood lipids,IL-6 and hs-CRP in control treatment group and treatment group were significantly reduced,as compared with those before treatment (P0.01),furthermore the decrease in treatment group was more obvious than that in control treatment group (P0.01),however,the decrease of blood lipid levels before treatment in control treatment group and treatment group was not related with the decrease of levels of IL-6 and hs-CRP (P0.05).Conclusion The atorvastatin can reduce the levels of blood lipid,IL-6 and hs-CRP in patients with UAP,and the effect of atorvastatin 20mg is superior to that of atorvastatin 10mg,however,its anti-inflammatory effect is not independent of the effect of reducing blood lipid.