The clinical significance of platelet antibody detection and platelet cross-matched on platelet transfusion refractoriness

Objective To evaluate the clinical significance of platelet antibody detection and platelets cross-matched on platelet transfusion refractoriness by comparing the efficiency of transfusion before and after platelets cross-matched.Methods Regarding the improvement of haemorrhage symptom,corrected count increment(CCI),percent platelet recovery(PPR) as the standard,the efficiency of transfusion of before and after platelets cross-matched were compared.Results In 25 cases of patients with platelet transfusion refractoriness,9 cases′ platelet antibody detection were positive.Transfusion efficiency rates of 9 cases were significantly different before and after platelets cross-matched(P0.01).The values of CCI and PPR in 1 h and 24 h after transfusion were higher than before.Conclusion Platelet antibody detection and platelet cross-matched can improve the efficiency of single-donor platelet transfusion,and also avoid misusing platelet.