Effect of Valsartan to Expression of p27 in the Kidney of Diabetic Rats

Objective To observe the effect of valsartan to expression of p27.Methods The rats were divided into two groups:normal group and diabetes group.The latter were were made into diabetes rat models by injecting streptozotocin-induced(STZ) into their abdominal cavities at a time,and were grouped by the therapy methods into valsartan treatment group and non-treatment group.When the diabetic models had been induced,valsartan group were treated with valsartan,and the normal group,none-treatment diabetes group had a lavage with the same volume of drinking water.After eight weeks,the rats were observed to detect plasma glucose,renal relative weight,BUN,24 h total urine proteins,24 h urine albumin protein and the expression of p27 in kidney.Results Compared with the DMN group,valsartan reduced renal relative weight,BUN,24 h urine total proteins,24 h urine albumin protein and p27.The expression of p27 was significantly positively related to 24 h urine albumin protein.Conclusion Valsartan can reduce urinary protein excretion and protect renal function,which has some connection with reduction of the expression of p27.