Primary Malignant Melanoma of Cervix:Clinicopathologic Observations

Objective To explore the histopathologic and immunohistochemical characteristics of Primary malignant melanoma of cervix and its differential diagnosis.Methods We observed the histopathologic and immunohistochemical results in a case of Primary malignant melanoma of cervix and the related literature was reviewed.Results Histologically,locating under the mucosa,the tumor contained balloon-like cells,small cells and spindle cells,which are arranged in cords,sheets or diffuse type.The tumor cells were positive for Vimentin,S-100,and HMB-45 while negative for CK,NSE,Actin,Desmin and LCA.Conclusions HMB-45,Melan-A and S-100 protein play important roles in the diagnosis.It is worth noticing that the tumor should be differentiated from carcinoma,carcinosarcoma,lymphoma and choriocarcinoma.