Primary uterine cervix melanoma

The purpose of this paper is to present a rare clinical case of primary uterine cervix melanoma. Clinical data and histological specimens were a material for this investigation. The paper describes a case of primary uterine cervix melanoma in a 47-year-old patient who visited a gynecologist for contact bleeding from the genital tract. Squamous cell carcinoma was diagnosed by primary biopsy. Histologically, this tumor was referred to as a mixed tumor: there were large cell fields with epithelioid morphology and high mitotic activity among the small cell component. No pigment was detected. Immunohistochemical examination revealed the pronounced cytoplasmic expression of S-100 and a melanocytic cocktail (HMB-45 + tyrosinase + MelanA), a negative reaction in the tumor cells with smooth muscle actin and desmin and a positive reaction in the preserved myocytes, and the expression of cytokeratin AE1/AE3 exclusively in the non-keratinized surface stratified squamous epithelium. Primary epithelioid amelanotic melanoma was diagnosed.