2010•Journal of Ningxia Medical UniversityRequires access
Glutathione Intervention Hyperhomocysteimia Induced Atherosclerosis in Rabbits
Ning Hai-feng
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Abstract
Objective To explore the mechanism of atherosclerosis of Rabbit induced by Hyperhomocysteinemia.Methods 44 New Zealand white rabbits were randomly divided into 4 groups: the control group(A group) were given standard feed;the model group(B group) took 1% methionine diet 100 g·d-1 feeding;low-dose intervention group(C group) took 1% methionine diet 100g·d-1 feeding + Reduced Glutathione 15mg·d-1intramuscularly;high-dose intervention group(D group) took 1% methionine diet 100g·d-1 feeding + Reduced Glutathione 30mg·d-1intramuscularly.at 0 and the 8th week,rabbit central ear artery blood were taken and plasma total homocysteine levels,serum total cholesterol,triglyceride,C-reactive protein,super-oxide dismutase were detected.Results Plasma Hcy and C-reactive protein were significantly higher than those in control group.(P0.05).SOD activity were significantly lower than those in control group(P0.05).Glutathione intervention could reduce the serum Hcy concentrations and raise SOD activity(P0.05).Conclusion Glutathione can prevent the occurrence and development of atherosclerosis development by inhibiting the oxidative stress and inflammatory response.