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2006•Journal of Traditional Chinese OphthalmologyRequires access

The effect of sanxuemingmu(散血明目)tablet on connective tissue growth factor in traumatic rabbit eyes with proliferative vitreoretinopathy

Chen Ji

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Abstract

OBJECTIVE To study the effect of sanxuemingmu(散血明目)tablet on connective tissue growth factor(CTGF)in experimental traumatic proliferative vitreoretinopathy(PVR).METHODS Experimental PVR models were induced by posterior penetrating eye injury and platelet-rich plasma(PRP)was infused to the central vitreous cavity.The positive expression of CTGF in the proliferative membranes were examined by the immunohistochemical SABC.RESULTS Compared with normal control group and other control groups,the positive expression of CTGF was decreased in sanxuemingmu group( P0.05 ).CONCLUSIONS Sanxuemingmu tablet can decrease the positive expression of CTGF of the proliferative membranes from the vitreous,inhibit the development of PVR.

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What this paper is about

OBJECTIVE To study the effect of sanxuemingmu(散血明目)tablet on connective tissue growth factor(CTGF)in experimental traumatic proliferative vitreoretinopathy(PVR).METHODS Experimental PVR models were induced by posterior penetrating eye injury and platelet-rich plasma(PRP)was infused to the central vitreous cavity.The positive expression of CTGF in the proliferative membranes were examined by the immunohistochemical SABC.RESULTS Compared with normal control group and other control groups,the positive expression of CTGF was decreased in sanxuemingmu group( P0.05 ).CONCLUSIONS Sanxuemingmu tablet can decrease the positive expression of CTGF of the proliferative membranes from the vitreous,inhibit the development of PVR.

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Available abstract

OBJECTIVE To study the effect of sanxuemingmu(散血明目)tablet on connective tissue growth factor(CTGF)in experimental traumatic proliferative vitreoretinopathy(PVR).METHODS Experimental PVR models were induced by posterior penetrating eye injury and platelet-rich plasma(PRP)was infused to the central vitreous cavity.The positive expression of CTGF in the proliferative membranes were examined by the immunohistochemical SABC.RESULTS Compared with normal control group and other control groups,the positive expression of CTGF was decreased in sanxuemingmu group( P0.05 ).CONCLUSIONS Sanxuemingmu tablet can decrease the positive expression of CTGF of the proliferative membranes from the vitreous,inhibit the development of PVR.

Key concepts: Proliferative vitreoretinopathy, CTGF, Connective tissue, Growth factor, Medicine, Immunohistochemistry, Ophthalmology, Pathology

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The effect of sanxuemingmu(散血明目)tablet on connective tissue growth factor in traumatic rabbit eyes with proliferative vitreoretinopathy — Research Paper | ScholarLens