1999•Traditional Chinese Drug Research and Clinical PharmacologyRequires access

The Influence of Yangwei Granule on the Structure of Gastric Mucosa and Plasma in Rat Models with Chronic Atrophic Gastritis

Zhaobao Yin

Abstract

Setting up rat model of chronic atrophic gastritis(CAG) by using Methylnitronitrosoguanidine(MNNG) and alcohol,to observe the effect of Yangwei Granule(YWG)on gastric mucosa,prostaglandin E 2(PGE 2),somatostatin(SS) and plasma Motilin(MOT).Results:YWG could alter the structure of gastric mucosa,increase the level of PGE 2 and SS as compared with the control group ,the difference being significant (P 0.05), while that of MOT was not significant(P 0.05). Conclusion:YWG can protect the gastric mucosa and repair its damage by regulating the secretion of gastrointestinal hormone.

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Key concepts: Gastric mucosa, Internal medicine, Motilin, Atrophic gastritis, Somatostatin, Granule (geology), Secretion, Endocrinology