Expression of survivin,bax and bcl-2 in non-small-cell lung cancer and its significance

Objective To study the relationship between the expression of survivin,bcl-2 and bax and NSCLC.Methods Apoptosis,PCNA,survivin,bax and bcl-2 expression were detected with TdT-mediated dUTP-biotin nick and labeling(TUNEL)and immunohistochemistry methods in 163 cases of NSCLC.Results The positive rates of survivin,bcl-2 and bax in NSCLC were 69.9%,62.0 %,52.8 % and 1.9 %,29.2 %,93.47% in normal lung tissues respectively.There were significant differences between NSCLC group and normal lung tissues group(P 0.05).There was positive correlation existing in the expression of survivin and bcl-2 in lung cancer.Apoptosis index,the ratio of apoptosis indexs to PCNA indexs,survivin,bax and bcl-2 protein expression were well correlated with the pathological grading and clinical stage(P 0.05).Conclusion The abnormal change of cell apoptosis and proliferation and survivin,bcl-2 and bax overexpression play a significant role in the occurrence and progression of NSCLC.The expression of survivin and bcl-2 have relationship with the genesis and development of NSCLC,and may play a role in the pathway of lung cancer and be identified as a definite diagnostic and reflecting biological behavior marker in NSCLC.