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2008•International Journal of Pathology and Clinical MedicineRequires access

Immunomodulatory character and application on stem cell transplantation of mesenchymal stem cells

Zhao Shi

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Abstract

Mesenchymal stem cells,a kind of adult stem cell from bone marrow,have idiopathic negative immunomodulatory character.They can affect the function of T lymphocytes,B lymphocytes,NK cells and dendritic cells via cell-to-cell contact,secreting cytokines such as transform growth factor beta(TGF-β),or modulating the metabolism of these cells.Through these ways mesenchymal stem cells has promising prospect on the rebuilding of immune system and graft-versus-host disease after stem cell transplantation.

About this research paper

What this paper is about

Mesenchymal stem cells,a kind of adult stem cell from bone marrow,have idiopathic negative immunomodulatory character.They can affect the function of T lymphocytes,B lymphocytes,NK cells and dendritic cells via cell-to-cell contact,secreting cytokines such as transform growth factor beta(TGF-β),or modulating the metabolism of these cells.Through these ways mesenchymal stem cells has promising prospect on the rebuilding of immune system and graft-versus-host disease after stem cell transplantation.

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Available abstract

Mesenchymal stem cells,a kind of adult stem cell from bone marrow,have idiopathic negative immunomodulatory character.They can affect the function of T lymphocytes,B lymphocytes,NK cells and dendritic cells via cell-to-cell contact,secreting cytokines such as transform growth factor beta(TGF-β),or modulating the metabolism of these cells.Through these ways mesenchymal stem cells has promising prospect on the rebuilding of immune system and graft-versus-host disease after stem cell transplantation.

Key concepts: Mesenchymal stem cell, Clinical uses of mesenchymal stem cells, Stem cell, Stem cell transplantation for articular cartilage repair, Cell biology, Transplantation, Biology, Adult stem cell

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