Expression of TFF3 in rats with acute gastric mucosal lesion treated by Teprenone and Rabeprazole

Objective To explore the expression of TFF3 and the protective role of Teprenone and Rabeprazole in rats with acute gastric mucosal lesion. Method Forty wistar male rats were randomly assigned into normal control group,model group,teprenone group,rabeprazole group and teprenone / rabeprazole group,with 8 rats in each group. Acute gastric mucosal lesion model was induced by absolute ethylalcohol. Gastric tissue pathological changes were performed by hematoxylineosin staining,and gastric ulcer index was evaluated. Expression of TFF3 in gastric mucosa was detected by immune histochemical method. Results( 1) UI of drug treatment groups was significantly lower than that of model group( P 0. 01); UI of combination group was lower than that of teprenone group( P 0.05); UI of combination group was lower than that of rabeprazole group( P 0. 01).( 2) Hematoxylineosin staining results were as follows: Compared with control group,epithelial cells were deficient on gastric mucosa surface in model group,with a large number of inflammatory cells infiltration as well as muscularis and serosa destroyed; By comparison with model group,in rabeprazole group,teprenone group and rabeprazole / teprenone group deficiency of epithelial cells of gastric mucosa surface was less,mucous glands reappeared,and serous membrane structure was relatively complete with less inflammatory cells and exudate.( 3) Immunohistochemical results were as follows: Expression of TFF3 positive cells in model group and drug intervention group was significantly increased,which was significantly higher than that in normal control group( P 0. 05). Conclusion Rabeprazole and teprenone may protect gastric mucosa tissues by raising TFF3 expression,promote the healing of gastric mucosa and alleviate the acute gastric mucosa injury in rats.