Clinical curative effect of low dose heparin combined with Xuebijing in the treatment of sepsis

Objective To observe the clinical effect of low dose heparin combined with Xuebijing in the treatment of sepsis. Method 78 cases of sepsis patients in our hospital from April 2008 to April 2013 were chose as the subjects of study, and they were divided into observation group and control group according to the random number table method, 39 cases in each group. All patients were treated with conventional therapy, and received intravenous drip of Xuebijing. Observation group patients were treated with low dose of heparin on the basis of the above treatment. While the same dose of saline was added in control group. Coagulation parameters, inflammatory factors, APACHE Ⅱ score, liver and kidney function changes, adverse reactions and prognosis between the two groups were compared. Result After treatment, PLT, FIB levels were significantly increased in the two groups(P 0.05), and D-D level significantly decreased(P 0.05), with more significant changes in observation group(P 0.05). After treatment, APTT, PT in observation group significantly reduced(P 0.05), with no significant change in control group(P 0.05). After treatment, IL-6, TNF-α levels and APACHE Ⅱ score were significantly decreased in the two groups(P 0.05), observation group decreased more significantly(P 0.05). IL-10 level in the two groups had no significant changes before and after treatment(P 0.05). After treatment, ALT, AST, BUN, SCr levels significantly decreased(P 0.05). SCr level decreased more significantly in observation group(P 0.05). During the treatment, the two groups patients had no active bleeding, allergies and other adverse reactions. The mortality rate in observation group was significantly lower than control group(P 0.05), the mean survival time was significantly higher than control group(P 0.05). Conclusion Low dose heparin combined with Xuebijing injection can effectively improve the blood coagulation function and reduce inflammatory level, with exact curative effect and safety, worthy of clinical promotion.