2003•Chinese Remedies & ClinicsRequires access

Clinical observation on slow-acting antirheumatic drugs combination on rheumatoid arthritis

Dong Bai Sun

Abstract

Objective To observe the efficacy and safety of two kinds of slow acting antirheumatic drugs (SAARDs) on rheumatoid arthritis (RA).Methods Fifty patients with active RA were randomly divided into two groups.One group was treated with methotrexate (MTX) 10 mg/week and tripterygium glycosides (TG) 60 mg/day.Another group with MTX 10 mg/week and salicylazosulfapyridine (SASP) 2 0 g/day,for 12 weeks.Results The efficacy rate in the MTX+TG group was 84% and 92%,respectively on week 6 and week 12.The MTX+SASP group was 56% and 88%.Conclusion The efficacy of MTX+TG and MTX+SASP to treat RA is similar.Both are better than MTX alone,with side effects not increased.

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Key concepts: Methotrexate, Rheumatoid arthritis, Medicine, Antirheumatic drugs, Tripterygium, Internal medicine, Gastroenterology, Arthritis