Analysis of the serum uric acid levels in Parkinson's disease

Objective To analyse the blood uric acid levels in Parkinson's disease(PD),and to discuss the relationships between serum uric acid levels and clinical stages,cognitive dysfunction.Methods Forty-three cases of Parkinson's disease which came from the Second Hospital of Jilin University from 2007 to 2008 were collected as PD group,then registrated the history,carried the UPDRS III scale and MMSE scale,determined the Hoehn-Yahr stage;At the same time the health person were collected from the Health Examination Centers whose age,sex,and education matched with PD group as the normal control group.The levels of serum uric acid in the two guoups were examined and compared(P0.05 considered to be statistically significant).Results The serum uric acid levels in PD group were significantly lower than those in normal control group(P0.01);It had no significant difference between different Hoehn-Yahr stage period of PD group(rs=0.137,P0.05);The serum uric acid levels of any stages of PD patients were lower than the normal control group(P0.05);The MMSE score between PD group and normal control group had no significant difference(P0.05).Conclusion Low level of the serum uric is likely to be a risk factor for PD,but can not be used to assess the severity of disease,and serum uric acid levels can be used as an early biological marker for PD.MMSE scale used to determine the cognitive impairment in PD is not sensitive enough.