Clinic study on uric acid in patients with Parkinson′s disease

Objective To explore the relation between uric acid in patients with Parkinson′s disease(PD) and motor symptoms and non-motor symptoms.Methods 101 patients with PD were classified as PD,male PD and female PD groups and their serum uric acid contents were examined,and 100 healthy persons whose age,sex matched the patients were enrolled as the controls.We used unified Parkinson diseases rating scale part Ⅲ,the PD NMS Questionnaire and Montreal Cognitive Assessment and Hamilton Depression Rating Scale to assess the patients.Results The serum uric acid level in PD(315.4±71.83 μmol/L) was lower than that in the controls [(332.06±83.36)μmol/L,P0.05].The serum uric acid level in PD was gender related and male PD patients(336.01±74.72) μmol/L had a higher serum uric acid level than female patients[(293.25±108.84)μmol/L,P0.05].In male PD patients,the serum uric acid level was correlated with clinical types(r=0.342,P0.05).In PD patients(r=-0.255,P0.05)and female PD patients(r=-0.32,P0.05),the serum uric acid level was correlated with mood and recognition symptoms in NMS Quest.Conclusion Lower serum uric acid level is probable a risk facor in PD.There are some correlations between serum uric acid level and motor symptoms and non-motor symptoms,which needs further investigation.