Relationship between biomarkers of infammation and angiotensin II and plasma renin activity among Mongolians

Objective To explore the relationship between biomarkers of infammation and angiotensin Ⅱ(AngⅡ) and plasma renin activity(PRA) among Mongolians.Methods The data on demographics etc.were collected,blood pressures were measured and C-reactive protein(CRP),soluble E-selectin(sE-selectin),soluble intercellular adhesion molecule 1(sICAM-1),AngⅡ and PRA were examined for 2 589 Mongolian.Logistic regression was used to analyze the association between the biomarkers and abnormal AngⅡ and PRA among Mongolian.Results The average levels of sE-selectin was signifcantly higher in the participants with abnormal PRA than those with normal PRA(18.9 vs 17.5 ng/ml,P0.001).Compared with the lowest quartile of sE-selectin,the multivariable-adjusted odds ratio(95% confident interval) of abnormal PRA for the highest quartile was 1.42(1.08~1.87).The average levels of both CRP(6.3 vs 5.5 mg/L) and sICAM-1(335.3 vs 314.4 ng/ml) were signifcantly higher in the participants with abnormal AngⅡ than those with normal AngⅡ.Compared with the lowest quartile of CRP,the multivariable-adjusted odds ratio(95% confident interval) of abnormal Ang Ⅱ for the highest quartile was 1.94(1.44~2.60);compared with the lowest quartile of sICAM-1,the multivariable-adjusted odds ratio(95% confident interval) of abnormal AngⅡ for the highest quartile was 1.44(1.11~1.87).Conclusion The levels of sE-selectin is associated with abnormal PRA,and the levels of CRP and sICAM-1 are associated with abnormal AngⅡ.