Relationship between inflammatory biomarkers and hypertension in a Mongolian population with normal body mass index

Objective To explore the association between inflammatory biomarkers and hypertension among Inner Mongolians without overweight or obesity. Methods In this cross-sectional study, 1784 Mongolians with normal body mass indexes were recruited. Baseline characteristics were collected. Subjects were divided into hypertension group(n=583)and normotension group (n=1201) . Angiotensin Ⅱ (Ang Ⅱ), high-sensitivity C-reactive protein (hsCRP), soluble intracellular adhesion molecule 1 (sICAM-1) and soluble E-selectin (sE-selectin) were examined. Covariance analysis was used to examine the relationship between inflammation biomarkers and systolic blood pressure and diastolic blood pressure. The odds ratios of hypertension were calculated using nonconditional logistic regression models. Results Compared with normotension group, the plasma level of Ang Ⅱ, hsCRP, sICAM-1 and sE-selectin were all significantly higher in hypertension group [52.0(40.8,85.9) vs 47.0(39.3, 65.8)ng/L, 6.7(4.4, 13.7) vs 5.3(3.5,9.2)mg/L, (334.3±98.0) vs (320.1±95.4)μg/L, 18.5(15.0,24.4) vs 17.9(14.1,23.4)μg/L, respectively, all P0.05]. After adjusting the age, gender, smoking, drinking, waist circumference and hypertension family history, covariance analysis showed that mean levels of systolic and diastolic blood pressures increased with the increasing Ang Ⅱ and hsCRP. Multivariate logistic regression showed that odds ratio of hypertension were 1.005 for Ang Ⅱ and 1.018 for hsCRP. Conclusion Elevated plasma levels of Ang Ⅱ and hsCRP are associeted with the increase of blood pressure in Inner Mongolians with normal body mass index.