Protective effects of Prostaglandin E_1 in rat hepatic ischemia/reperfusion injury

Objective To observe the protective effect of PGE1 in rat ischemia-reperfusion injury and to investigate the possible mechanism.Methods After the model of in situ hepatic I/R injury was established in 24 rats,the rats were randomly divided into sham operation(S) group,ischemia-reperfusion(I/R) group and Prostaglandin E1(PGE1) group.The serum concentrations of liver enzyme levels,superoxidase dismutase(SOD),malondialdehyde(MDA) and myeloperoxidase(MPO) were measured respectively,and the hepatic pathological changes were observed.Results The liver enzyme levels,MDA and MPO were significantly higher,and activity of SOD was lower in groups of I/R and PGE1 group than those in S group(P0.01).Compared with I/R group,liver functional parameters,MDA and MPO were lower in PGE1 group(P0.01),and the activity of SOD was higher in PGE1 group(P0.01);meanwhile,the hepatic congestion and pathological damage were also obviously relieved in PGE1 group.Conclusions PGE1 could relieve the I/R injury of liver,and the mechanism may be by improving tissue antioxidation capability and decrease of neutrophilic leukocyte aggregation.