Study on high-risk HPV DNA detection in the diagnosis and treatment of ervical lesions

Objective:To study the value of high-risk HPV in cervical intraepithelial neoplasia (CIN) and cervical cancer.Methods:357 cases outpatients from Liaoning Cancer Hospital during January 2004 to May 2005 were studied.The cervical lesion were confirmed by colposcopy biopsy and HPV DNA was tested with hybrid capture method.Results:The ratio of high-risk HPV detected in CINⅠ,CINⅡ,CINⅢ group and cervical cancer group was 49.1%,57.9%,92.5%,98.3% respectively.There was significant difference between test group and control group (P0.05);The sensitivity of diagnosis of CINⅢ and cervical cancer by high-risk HPV test was 96.0%,the speciality was 59.3%,the positive predictive value was 48.0%,the negative predictive value was 97.5%;The ratio of high-risk HPV in those older than 30 years was 44.8% ~90.0%,which was consistent with the occurece of CINⅢ and cervical cancer.Conclusion:Infection rate of high-risk HPV is ascending with serious degree of cervical disease;The sensitivity and negative predictive value of high-risk HPV test in diagnosing CINⅢ and cervical cancer is high;Test of high-risk HPV DNA is very useful to screen cervical cancer in the women over 30 years old.