2006•PubMedRequires access
[Effects of Naoan tablets on brain hemodynamics and cerebral microcirculation of soft membrane in anesthetized dogs and rats].
Dafang Zhang, Xiuhua Wang, Lijing Li, Wenjing Cai, Yajie Zhang
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Abstract
OBJECTIVE: To study the effects of Naoan tablets on brain hemodynamics and cerebral microcirculation of soft membrane. METHOD: Cerebral blood stream flux, resistance of blood vessels, blood pressure and heart rate were used as observation indexes in hemodynamics experiment. Artery caliber and the number of capillaries with recovered blood stream were used as observation indexes in microcirculation experiment. RESULT: Naoan tablets at dose of 0.5 g x kg(-1) and 1.0 g x kg(-1) could enhance cerebral blood stream flux, decrease resistance of blood vessels, and reduce blood pressure. While no effects on heart rate. Naoan tablet at dose of 0.7 g x kg(-1) and 2.1 g x kg(-1) could increase the number of capillaries with recovered blood stream and enlarge the artery caliber of soft membrane in rats. CONCLUSION: Naoan tablets can improve the indexes of hemodynamics and cerebral microcirculation of soft membrane.