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2004•Journal of Jiangsu Clinical MedicineRequires access

A DOUBLE-BLIND RANDOMIZED CLINICAL STUDY IN MULTIPLE-CENTER COMPARING THE EFFECT OF NATELGINIDE ON TYPE 2 DIABETES WITH REPAGLINIDE

Zheng Xu, Pla Fuzhou

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Abstract

Objective: To evaluate the effect and safety of nateglinide on type 2 diabetes. Methods: A double、blind randomized clinical study in the multiple、center comparison with the effects of nateglinide on type 2 diabetes and repaglinide in 2 groups for 14 weeks of experiement and 12 weeks of observntion. Rusults: After 12 weeks, nateglinide significantly reduced the hemoglobin A(1c) (HbA1c), Fasting blood glucose (FBG) and 2h postprandial blood glucose(2hPBG)as well as repaglinide(P0.05). Nateglinide and repaglinide tended to decrease the total cholesterol (TC) and triglyceride (TG), but only nateglinide can reduce triglyceride (TG) significantly (P0.05). Theratesofsidereactionsfornateglinideandrepaglinidewere1.74%and 1.75% respectively (P0.05). Conclutions: Nateglinide appeared to be effective and safe in the treatment of type 2 diabetes, which is similar to repaglinide.

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Objective: To evaluate the effect and safety of nateglinide on type 2 diabetes. Methods: A double、blind randomized clinical study in the multiple、center comparison with the effects of nateglinide on type 2 diabetes and repaglinide in 2 groups for 14 weeks of experiement and 12 weeks of observntion. Rusults: After 12 weeks, nateglinide significantly reduced the hemoglobin A(1c) (HbA1c), Fasting blood glucose (FBG) and 2h postprandial blood glucose(2hPBG)as well as repaglinide(P0.05). Nateglinide and repaglinide tended to decrease the total cholesterol (TC) and triglyceride (TG), but only nateglinide can reduce triglyceride (TG) significantly (P0.05). Theratesofsidereactionsfornateglinideandrepaglinidewere1.74%and 1.75% respectively (P0.05). Conclutions: Nateglinide appeared to be effective and safe in the treatment of type 2 diabetes, which is similar to repaglinide.

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Available abstract

Objective: To evaluate the effect and safety of nateglinide on type 2 diabetes. Methods: A double、blind randomized clinical study in the multiple、center comparison with the effects of nateglinide on type 2 diabetes and repaglinide in 2 groups for 14 weeks of experiement and 12 weeks of observntion. Rusults: After 12 weeks, nateglinide significantly reduced the hemoglobin A(1c) (HbA1c), Fasting blood glucose (FBG) and 2h postprandial blood glucose(2hPBG)as well as repaglinide(P0.05). Nateglinide and repaglinide tended to decrease the total cholesterol (TC) and triglyceride (TG), but only nateglinide can reduce triglyceride (TG) significantly (P0.05). Theratesofsidereactionsfornateglinideandrepaglinidewere1.74%and 1.75% respectively (P0.05). Conclutions: Nateglinide appeared to be effective and safe in the treatment of type 2 diabetes, which is similar to repaglinide.

Key concepts: Nateglinide, Repaglinide, Medicine, Postprandial, Type 2 diabetes, Internal medicine, Triglyceride, Glibenclamide

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A DOUBLE-BLIND RANDOMIZED CLINICAL STUDY IN MULTIPLE-CENTER COMPARING THE EFFECT OF NATELGINIDE ON TYPE 2 DIABETES WITH REPAGLINIDE — Research Paper | ScholarLens