Expression of MicroRNA-141 in Tissue and Serum of Patients with Ovarian Epithelial Carcinoma and Its Clinical Significance

Objective: To investigate the expression of microRNA-141(miR-141)in epithelial ovarian cancer samples and to investigate the possibility of serum miR-141 used as biomarker for epithelial ovarian cancer.Methods: The expression of miR-141 in tissues and serum from 16 cases of epithelial ovarian cancer and 4 cases of normal persons and in serum from 4 cases of benign epithelial ovarian tumor was detected by real-time RT-PCR.Results: The expression of miR-141 in epithelial ovarian cancer tissues was significantly higher than those in normal persons(P0.05).The expression of miR-141 in epithelial ovarian cancer serum was significantly higher than those in benign epithelial ovarian tumor and normal persons(P0.05),but there was no difference between the latter two groups.The expression of miR-141 increased with the progression of the clinical stages(P0.01),but it had not correlation with histological grading and the increasing of CA125(P0.05).There was no difference for miR-141 expression with clinicpathologic features in tissues of patient of epithelial ovarian cancer(P0.05).Conclusion: MiR-141 might play a role as an oncogene in the occurrence and development of ovarian epithelial carcinoma.MiR-141 has higher sensibility and specificity,and it is expected to become a new target of early diagnosis of ovarian cancer.