Contrust Study on Treatment of Primary Trigeminal Neuralgia with Gabapentin

Objective A total of to investigate the effects,security and tolerance of gabapentin for primary trigeminal neuralgia.Method 68 patients with primary trigeminal neuralgia were divided randomly into two groups.These two groups were treated by gabapentin or carbamazepine respectively for 10 weeks.During this period,the degree of ache(VAS score),the dosage and the side effects of patients were observed and recorded.Results After 4 weeks of gabapentin treatment,the obvious effective rate was 61.8%,and the total effective rate was 88.2%,the VAS score reduced significantly.After 2 weeks of carbamazepine treatment,the obvious effective rate was 64.7%,and the total effective rate was 91.2%,the VAS score reduced significantly.There were no significant differences between two groups in the clinical efficacy(P0.05),while gabapentin group had lower adverse reaction rate.However,the onset time of carbamazepine group was significantly shorter than that of gabapentin group(P0.01),but after 4 weeks,there was no significant differences in VAS score in two groups.Conclusions The efficacy of gabapentin and carbamazepine for primary trigeminal neuralgia is equivalent,and gabapentin has no serious adverse reactions,it is worthy spreading.