Therapeutic effect of hemoperfusion combined with hemodialysis on patients with paraquat intoxication

Objective To analyze the survival rate and prognostic factors in paraquat intoxication patients treated with hemoperfusion combined with hemodialysis(HP+HD). Methods A total of 67 paraquat intoxication patients treated in this hospital in the period from June 2010 to May 2013 were retrospectively analyzed. They were divided into control group, HP+HD group and enhanced HP+HD group base on the treatment method. Kaplan-Meier analysis was performed for the estimation of survival rate, which was then compared among the three groups by using the log-rank test. Cox regression was used for multivariate analysis. Results The survival rate after the treatment for 30 days was 20.8%, 30.2%, and 37.0% in control group, HP+ HD group and enhanced HP+HD group, respectively. The survival curve was statistically different among the three groups(χ2=6.22, P = 0.04). The RR value was 0.81(P=0.00) for HP+HD frequency, 1.04(P=0.01) for paraquat intoxication amount, and 1.19(P=0.00) for plasma paraquat concentration before treatment. Conclusions The enhanced HP+HD group had the highest survival rate among the three groups. HP+HD frequency, paraquat intoxication amount, and plasma paraquat concentration before treatment were the independent factors affecting prognosis. HP+HD can improve the survival rate in patients with paraquat intoxication.