Effect of intensive hemoperfusion on the survival rate and complications of acute paraquat poisoning

Objective To evaluate the effect of intensive hemoperfusion(IHP) in the treatment of acute paraquat poisoning. Methods Fifty-two patients diagnosed as acute paraquat poisoning were included in the study. The patients were divided into two groups:group A(intensive hemoperfusion,2 times everyday for one week,n=28),group B (conventional hemoperfusion,once everyday for one week,n=24). Patients in the two groups underwent the same conventional treatment except for the HP. Mortality and complication rates were compared among the two groups,and white blood cell (WBC),arterial oxygen partial pressure(PaO2),C-reactive protein(CRP),serum creatinine(Cr),retinol-binding protein (RBP) were analyzed. Results The mortality rates, incidence of acute kidney injury, incidence of ARDS had statistic differences between group A and group B(χ2=6.39,7.08,6.39,P0.05). Compared with group B,the level of WBC and CRP in group A was significantly reduced(t=5.06,5.57,P0.05) and the level of PaO2 was increased(t=7.02,P0.05). The level of serum Cr and RBP were significantly reduced(t=3.61,10.81,P0.05). Conclusions Compared with traditional hemoperfusion,intensive hemoperfusion can significantly reduced the mortality in the patients with paraquat poisoning. Further more,the intensive hemoperfusion can significantly lower the level of WBC and CRP and improve the oxygenation.