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2009•Medical Journal of the Chinese People's Armed Police ForcesRequires access

Preparation of omeprazole enteric coated pellets by centrifugal granulation

Gang Wang

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Abstract

Objective To prepare omeprazole enteric coated pellets.Methods Centrifugal granulation was performed to prepare omeprasole pellets.The mixture of HPMC and tale was used to subcoat the pellets.Enteric-coating material,Eudragit L30D-55,was used to coat the pellets.Results The stability of omeprazole pellets was improved when the pellets were subcoated with the mixture of HPMC and talc.Meanwhile,the application of Eudragit ~ L30D-55 made the dissolution of the pellets meet the enteric release require- ments.Conclusions Centrifugal granulation can be used to prepare omeprazole enteric pellets.The process is easy with excellent reproducibility, the pellets present a profound dissolution profile.

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What this paper is about

Objective To prepare omeprazole enteric coated pellets.Methods Centrifugal granulation was performed to prepare omeprasole pellets.The mixture of HPMC and tale was used to subcoat the pellets.Enteric-coating material,Eudragit L30D-55,was used to coat the pellets.Results The stability of omeprazole pellets was improved when the pellets were subcoated with the mixture of HPMC and talc.Meanwhile,the application of Eudragit ~ L30D-55 made the dissolution of the pellets meet the enteric release require- ments.Conclusions Centrifugal granulation can be used to prepare omeprazole enteric pellets.The process is easy with excellent reproducibility, the pellets present a profound dissolution profile.

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Available abstract

Objective To prepare omeprazole enteric coated pellets.Methods Centrifugal granulation was performed to prepare omeprasole pellets.The mixture of HPMC and tale was used to subcoat the pellets.Enteric-coating material,Eudragit L30D-55,was used to coat the pellets.Results The stability of omeprazole pellets was improved when the pellets were subcoated with the mixture of HPMC and talc.Meanwhile,the application of Eudragit ~ L30D-55 made the dissolution of the pellets meet the enteric release require- ments.Conclusions Centrifugal granulation can be used to prepare omeprazole enteric pellets.The process is easy with excellent reproducibility, the pellets present a profound dissolution profile.

Key concepts: Pellets, Granulation, Omeprazole, Enteric coating, Enteric coated, Talc, Dissolution, Materials science

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