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2003•Zhōnghuá yàoxué zázhìRequires access

Preparation and optimization of the formulation of enteric coated omeprazole pellets

Dawei Chen

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Abstract

OBJECTIVE To develop the enteric coated omeprazole pellets.METHODS The enteric coated omeprazole pellets were prepared with extrusion-spheronization and air-flow coating method and the formulation was optimized by orthogonal design.RESULTS The resistance to acid was good and the dissolution of the pellets was quick in artificial intestinal liquid.CONCLUSION The problem of omeprazole's stability was resolved effectively and the preparation process was simple,feasible and replicable.It is worth further development and application in industry.

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What this paper is about

OBJECTIVE To develop the enteric coated omeprazole pellets.METHODS The enteric coated omeprazole pellets were prepared with extrusion-spheronization and air-flow coating method and the formulation was optimized by orthogonal design.RESULTS The resistance to acid was good and the dissolution of the pellets was quick in artificial intestinal liquid.CONCLUSION The problem of omeprazole's stability was resolved effectively and the preparation process was simple,feasible and replicable.It is worth further development and application in industry.

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Available abstract

OBJECTIVE To develop the enteric coated omeprazole pellets.METHODS The enteric coated omeprazole pellets were prepared with extrusion-spheronization and air-flow coating method and the formulation was optimized by orthogonal design.RESULTS The resistance to acid was good and the dissolution of the pellets was quick in artificial intestinal liquid.CONCLUSION The problem of omeprazole's stability was resolved effectively and the preparation process was simple,feasible and replicable.It is worth further development and application in industry.

Key concepts: Pellets, Omeprazole, Enteric coated, Enteric coating, Coating, Dissolution, Materials science, Chromatography

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