Expression Changes and Clinical Significance of Serum MMP-9 and hs-CRP in Coronary Heart Disease Patients with Type 2 Diabetes Mellitus

Objective To explore the expression levels and clinical value of serum matrix meta1loproteinase-9(MMP-9) and high sensitive C-reactive protein(hs-CRP) in coronary heart disease(CHD) patients with type 2 diabetes mellitus(T2DM). Methods Forty-five CHD patients with T2DM,40 patients with T2DM and 42 patients with CHD were selected from Department of Internal Medicine,Shijie Hospital of Dongguan.30 healthy volunteers were served as control group.Serum MMP-9 was measured with ELISA,hs-CRP in serum was measured by immunoturbidimetric method. Results The expression levels of MMP-9 and hs-CRP in CHD with T2DM group were significantly higher than those in CHD group,T2DM group and control group(P0.05).The expression levels of MMP-9 and hs-CRP in CHD group and T2DM group were significantly higher than those in control group.Spearman analysis showed that MMP-9 was positively correlated with hs-CRP in CHD with T2DM group(r=0.526,P0.01). Conclusions Combined detection of serum MMP-9 and hs-CRP is more conducive to monitoring the occurrence of diabetes related coronary atherosclerosis and forecasting the prognosis of the patients.