A Correlation Study in Serum MMP-9 and Inflammatory Factor in T2DM Patients with CHD

Objective To observe the levels of serum Matrix metallopeptidase 9(MMP-9),High-sensitive C-reactive protein(hs-CRP),IL-6 and IL-18,discuss the correlation between serum MMP-9 and inflammatory factor and its clinical value.Methods Total 182 cases of clinical diagnosed T2DM patients were divided into T2DM group and T2DM with CHD(T2DM+CHD) group.The levels of serum MMP-9 IL-6 and IL-18 were detected with ELISA,hs-CRP was measured with particle-enhanced turbidimetric immunoassay(PETIA).The results were analyzed using statistical methods.Results The levels of serum MMP-9,hs-CRP,IL-6 and IL-18 in T2DM group were significantly higher than those in the control group(P0.01);The levels of serum MMP-9,hs-CRP,IL-6 and IL-18 in the T2DM+CHD group were significantly higher than those in the T2DM group(P0.01).In the T2DM+CHD group,MMP-9 level was positive correlated to the levels of hs-CRP,IL-6 and IL-18(r=0.672,0.591,0.603,P0.01).Conclusion There were abnormal expressions of MMP-9 and hs-CRP and IL-6 and IL-18 in the high-risk T2DM patients,especially the T2DM+CHD patients.MMP-9 level was positive correlated to the levels of inflammatory factors.MMP-9,hs-CRP,IL-6 and IL-18 may participate in the events of CHD complicated with T2DM.This study provides a theory basis for the early intervention of T2DM patients with CHD.