Protective Effect of Resveratrol on Intestinal Mucosal Ischemia-Reperfusion Injury in Rats with Severe Acute Pancreatitis

Objective To observe the influence of resveratrol on superoxide dismutase(SOD),malondialdehyde(MDA),intercellular adhesion molecule-1(ICAM-1) and vascular cell adhesion molecule-1(VCAM-1) of intestinal mucosal ischemia-reperfusion injury protection in rats with severe acute pancreatitis(SAP).Methods Fifty-four rats were divided into three groups randomly: sham operation group(SO group),SAP model group(SAP group) and resveratrol-treated group(Res group).SAP model was made by injecting sodium taurocholate 50 mg/kg to pancreatic bile duct and resveratrol was given intravenously at 5 min after inducing SAP model.The rats were sacrificed at 3 h,6 h and 12 h after inducing SAP model respectively by equal number.The levels of MDA,SOD,ICAM-1 and VCAM-1 and histological changes of small intestine were measured.Results The level of MDA in small intestine tissue in SAP group was significantly higher than that in SO group(P0.05),while the activity of SOD was significantly lower in the relevant tissues(P0.05).The expressions of ICAM-1 and VCAM-1 in SAP group were higher than those of SO group(P0.05).The activity of SOD in small intestine tissue in Res group was significantly higher than that in SAP group(P0.05);while the level of MDA was significantly lower in the relevant tissues(P0.05).The expressions of ICAM-1 and VCAM-1 in Res group were lower than those of SAP group(P0.05).Conclusions Oxygen free radicals are concerned with the process of pathological changes in intestinal mucosal ischemia-reperfusion in rats with SAP.Resveratrol might increase SOD activity and decrease MDA level to attenuate lipid peroxidation in small intestine of SAP,and reduce the expressions of ICAM-1 and VCAM-1 in intestine,thus diminish the damage of the intestine in SAP.And it acts as a protective effect to small intestinal ischemia-reperfusion injury.