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Inquiring Relation between Apolipoprotein E Gene Polymorphysm and the Alzheimer Disease

Huang Shao

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Abstract

Objective To study the distribution of Apo E gene in patients with Alzheimer desease, and analyse the relation between them . Methods ApoE genotyes of patients with Alzheimer desease and age-matched healthy controls were determined by using the polymerphism technique,subsequently to require the ralation between ApoE allele and AD . Results ApoE e4 allele of patients with AD was 20.4%,which obviously was higher than 7.5% of cotrols, but e3 allele of patients with AD was 64.8%, which was lower than 83.2% of cotrols.Conclusions In ApoE allele, e4 allele is a genetic suscetible factor in AD,and e3 allele is a protection factor.

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What this paper is about

Objective To study the distribution of Apo E gene in patients with Alzheimer desease, and analyse the relation between them . Methods ApoE genotyes of patients with Alzheimer desease and age-matched healthy controls were determined by using the polymerphism technique,subsequently to require the ralation between ApoE allele and AD . Results ApoE e4 allele of patients with AD was 20.4%,which obviously was higher than 7.5% of cotrols, but e3 allele of patients with AD was 64.8%, which was lower than 83.2% of cotrols.Conclusions In ApoE allele, e4 allele is a genetic suscetible factor in AD,and e3 allele is a protection factor.

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Available abstract

Objective To study the distribution of Apo E gene in patients with Alzheimer desease, and analyse the relation between them . Methods ApoE genotyes of patients with Alzheimer desease and age-matched healthy controls were determined by using the polymerphism technique,subsequently to require the ralation between ApoE allele and AD . Results ApoE e4 allele of patients with AD was 20.4%,which obviously was higher than 7.5% of cotrols, but e3 allele of patients with AD was 64.8%, which was lower than 83.2% of cotrols.Conclusions In ApoE allele, e4 allele is a genetic suscetible factor in AD,and e3 allele is a protection factor.

Key concepts: Apolipoprotein E, Allele, Alzheimer's disease, Internal medicine, Disease, Medicine, Allele frequency, Gene

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Inquiring Relation between Apolipoprotein E Gene Polymorphysm and the Alzheimer Disease — Research Paper | ScholarLens