2005•Harbin Yike Daxue xuebaoRequires access
The expression and clinical significance of c-kit and SCF in ovarian epithelial carcinoma
Chunfeng Wu
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Abstract
Objective To investigate the expression of c-kit in ovarian epithelial carcinoma and their clinical significance and analyse the relationship of the expression with the development of ovarian epithelial carcinoma.Methods Expression of c-kit proteins were retrospectively studied with immunohistochemistry in paraffin sections from 10 normal ovarian tissues,20 benign ovarian epithelial tumors,16 ovarian borderline epithelial tumors,and 58 ovarian epithelial carcinomas.Results The positive expression rate of c-kit in ovarian epithelial carcinomas was 63.79%,it was statistically higher than those in normal ovarian(0%) and benigh ovarian epithelial tumors(10.00%)(P0.01).The positive expression rate of ovarian borderline epithelial tumors was 43.75%,it was also statistically higher than those in normal ovarian and benigh ovarian epithelial tumors(P0.05);In ovarian epithelial carcinoma,the positive expression of c-kit in low differentiated grade group was higher than that in high and middle differentiated grade group(P0.05),it rose with the development of FIGO clinical stages and lymphatic metastasis;patients with positive expression of c-kit had a worse result than those with negative one.Conclusion The detection of c-kit proteins may be helpful to diagnosis,predicting prognosis and evaluating treatment of patients with ovarian epithelial carcinoma