Effect of Serum Sodium on Complications and Prognosis of Liver Cirrhosis

Objective To explore the relationship between serum sodium and complications and prognosis in patients with decompensation liver cirrhosis.Methods 235 decompensation cirrhosis patients were divided into light,moderate,severe hyponatremia groups and serum sodium normal group according to their serum sodium levels.The relationship between serum sodium levels and end-stage liver disease(MELD),Child-Pugh classification,incidences of complications and prognosis were analyzed respectively.Results In 235 patients,the incidence of hyponatremia was 54.04%.The lower serum sodium levels,the higher patients' MELD,Child-Pugh classifications and higher incidences of other complications including hepatic encephalopathy,spontaneous bacterial peritonitis,hypokalemia,hepatorenal syndrome cxcept for gastrointestinal bleeding,the more severe patients'ascites extent.The mortality in serum sodium normal group and light,moderate,severe hyponatremia groups was 7.09%,12.77%,28.95%,60.87% respectively,the mortality in severe hyponatremia group was significantly higher than that in moderate,light hyponatremia groups and serum sodium normal group,the mortality of moderate hyponatremia group was also significantly higher than that of serum sodium normal group(P0.01).Conclusion The hyponatrelnia closely correlate with MELD and Child-Pugh classifications,complications and prognosis in patients with decompensation liver cirrhosis,which suggests its monitoring can be one of the prognostic predictors in patients with liver cirrhosis.