Drug-induced Anaphylactic Shock or Death:Drugs and Prevention & Treatment

OBJECTIVE:To probe into the causes,regularities and characteristics of drug-induced anaphylactic shock or death in an effort to avoid or reduce the incidence of drug-induced anaphylactic shock or death.METHODS:Documents on drug-induced anaphylactic shock or death searched from CBMdisc and CHDL(1994-01～2009-08) were sorted,collected and analyzed.RESULTS:Of the total 166 anaphylactic-shock cases collected,anaphylactic shock occurred within 10 min in 82 cases,and within 30 min in 37 cases,i.e a total of 119 cases(71.69%) occurred within 30 min.Of all those categories of drugs that induced anaphylactic shock or death,leading the first four places were antimicrobial drug with 97 cases(58.43%),circulatory drugs with 17 cases(10.24%),nervous system drugs with 10 cases(6.02%) and vaccines with 7 cases(4.22%).The top 3 drugs that induced anaphylactic shock or death were penicillins(35 cases),cephalosporins(20 cases) and low molecular dextran(10 cases).CONCLUSION:It is advisable to strictly follow medication indications,obtain detailed drug allergy history before treatment.For elderly patients,special efforts should be paid to the treatment of underlying diseases and close monitoring on the advere drug reactions in an effort to ensure medicaiton safety.