Experimental study on the hemostatic and sealing effects of fibrinogen plus collagen sponge using in the surface of hepatic operative wound

Objective To investigate the effects of hemostatic and sealing surface of wound, and status of internal degradation.Methods 20 SD white rats were randomly divided into two groups, namely experimental and control group. Hemostasis was performed with fibrinogen plus collagen sponge in experimental group. Hemostasis was performed gelatin sponge in control group. Results In the incision of hepatic surface, the two kinds of hemostatic material could stop the bleeding immediately. Fibrinogen plus collagen sponge was adhered to the incision closely.However,the gelatin sponge was deciduous easily. In the hemostatic time and hemorrhagic volume, the fibrinogen plus collagen sponge group was better than that the gelatin sponge group during hepatic resection of white rats(P 0.05). Histological examimation:In the remission of wound inflammation,degradation of hemostatic materials and stimulated hepatic cell regeneration, the experimental group was superior to the control group. Conclusion Fibrinogen plus collagen sponge can effect to hemostasis. It is closely adhered to surface of wound and is absorbed quickly, and that it can induce regeneration of hepatic cells. Because of fibrinogen plus collagen sponge possesses a good effects in the local hemostasis, sealing tissue and stimulated hepatic cell regeneration, so, it is a excellent biologic material.