The changes of circulating inflammatory factors after operation in patients with obstructive sleep apnea hypopnea syndrome

Objective To observe the changes of circulating tumor necrosis factor-alpha(TNF-α),interleukin-6(IL-6) and high-sensitivity C-reactive protein(Hs-CRP) levels in patients with obstructive sleep apnea-hypopnea syndrome(OSAHS) before and after operation,and to assess the effect of surgical treatment on the levels of these inflammatory factors.Methods Forty-five cases of OSAHS confirmed by polysomnography(PSG) were selected as OSAHS group and matched for age and sex to 45 controls.Serum levels of TNF-α and IL-6 were detected by high-sensitivity ELISA.The Hs-CRP was measured by latex-enhanced turbidometry.The serum levels of these factors in OSAHS group before operation were compared with those of the control group and OSAHS group one year after operation.Results Serum levels of TNF-α,IL-6,and Hs-CRP in OSAHS group were higher than those in the control group(P(0.01)),and the levels in OSAHS group one year after operation were significantly lower than those before operation(P(0.01)).All the serum parameters were correlated positively with AHI,and negatively with LSaO_2.Conclusion Operative treatment can effectively correct circulating serum levels of TNF-α,IL-6 and Hs-CRP in patients with OSAHS.