Relationship between glucose tolerance changes and coronary pathological changes in patients with coronary heart disease

Objective To investigate the relationship between glucose tolerance changes and coronary pathological changes in patients with coronary heart disease.Methods The study enrolled 200cases of patients diagnosed with simple tolerance value normal(NGT group,n=132)and coronary heart disease with impaired glucose tolerance(IGT group,n =35),the coronary heart disease group(T2DM group,n =33).All patients underwent coronary angiography(CAG)75g oral glucose tolerance test to detect blood glucose,insulin and lipid content.The degree of coronary artery disease on CAG analysis,classification and evaluation of the extent of coronary stenosis were classified in accordance with the classification criteria of the American College of Cardiology.Results ①There were statistical differences among NGT,IGT and DM groups except hemoglobin(HbA1c),fasting blood glucose(FBG),2 hours postprandial blood glucose(PBG),triglyceride(TG)and high density lipoprotein cholosterol(HDL-C)(P 0.05).There were significant differences between IGT and NGT groups in fasting insulin(FINS)levels(P 0.05).② There were statistical difference of right coronary artery(RCA),left anterior descending coronary artery(LAD),left main trunk(LMT)between any two of the three groups(P 0.05).There were statistical difference of the left circumflex coronary artery(LCX),total stenosis index,and coronary artery distal lesions in the IGT group and the DM group by comparison with the NGT group(P 0.05).③The Gensini score of DM group was(144.32±22.90) points,that of IGT group was(94.29±16.83)points,and that of NGT group was(67.77±12.32)points.There was statistical difference of Gensini score in the DM,IGT group by comparison with the NGT group(P 0.01),but there was no statistical difference between the DM and the IGT group(P 0.05).Conclusion There is correlation between glucose tolerance changes and pathological changes in patients with coronary heart disease.Postprandial hyperglycemia may be the main reason for the development of coronary heart disease.