Relationship between nonalcoholic fatty liver disease and growth hormone

Objective To explore the relationship between non-alcoholic fatty liver disease(NAFLD) and growth hormone(GH).Methods Thirty-eight patients with NAFLD,42 patients without NAFLD were enrolled in this study.The levels of waist circumference(WC),serum growth hormone(GH),fasting plasma glucose(FPG),fasting insulin(FIns),total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),high sensitivity C reactive protein(hsCRP),alanine aminotransferase(ALT),gamma glutamyltransferase(GGT)were measured.Body mass index(BMI) and insulin resistance index(HOMA-IR) were calculated.Results In NAFLD group,the levels of GH and HDL-C were significantly lower than those in non-NAFLD group(P0.05);In NAFLD group,the levels of WC,BMI,FPG,FIns,HOMA-IR,TG,hsCRP,ALT,GGT were significantly higher than those in non-NAFLD group.The levels of GH and HDL-C were negatively correlated with NAFLD.The levels of WC,BMI,FPG,FIns,HOMA-IR,TG,hsCRP,ALT,GGT were positively correlated with NAFLD.Conclusions GH is closely related with NAFLD.Low-level GH may be a risk factor for NAFLD and may participate in the occurrence and development of NAFLD.