2012•Journal of Bethune Military Medical CollegeRequires access
Expression and clinical significance of ERCC1、TS protein in non-small cell lung cancer
Hongbin Wang
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Abstract
Objective To study the expression of ERCC1、TS protein in non-small cell lung cancer,and explore its clinical significance.Methods The expression of ERCC1 and TS protein in 51 patients with NSCLC was detected by immunohistochemical methods.Results The positive expression of ERCC1 and TS protein in 51 patients with NSCLC was 49.0% and 60.8% respectively which has no significant correlation with the patients'age,gender,histological types,clinical stages and lymph node metastasis status(P0.05).The positive expression of TS protein was related to differentiation degree(P0.05).The expression of ERCC1 and TS was positively correlated(P0.01).Conclusion The higher expression levels of ERCC1 and TS in NSCLC may become predictive biomarkers in individualized treatment of NSCLC.