COX-2 Polymorphism and Susceptibility to Esophageal Cancer: A Meta-analysis

Objective To investigate the relationship between cyclooxygenase-2(COX-2) gene polymorphism and genetic susceptibility to esophageal cancer.Methods e PubMed and EMbase databases were searched from the date of their establishment to January 1st,2011 to collect the case-control studies on COX-2 polymorphism and susceptibility to esophageal cancer.For the population genotype distributions of both esophagus cancer group and control group,their odds ratios(ORs) and 95% con dence intervals(CIs) were taken as the e ect indexes,either the xed or random e ect model was applied to conducted Meta-analysis in homozygote comparison,dominant and recessive genetic models,and the publication bias was assessed then.All statistical analyses were conducted with Stata11.0 so ware.Results A total of ve case-control studies were included.e results of meta-analyses showed for the COX-2-765GC polymorphism,the CC+GC genotype was associated with the risk of esophageal cancer in a dominant genetic model(CC+GC vs.GG: OR=1.806,95% CI 1.050 to 3.106);for the COX-2-1195GA polymorphism,the AA genotype was associated with the risk of esophageal cancer in homozygote comparison and recessive genetic models,the AA+GA genotype was associated with the risk of esophageal cancer in a dominant genetic model.Conclusion It is suggested that COX-2 polymorphism may be associated with genetic susceptibility to esophageal cancer.