The Clinical Observation on the Treatment of Diabetic Nephropathy Phase III～V(Qi-Yin Deficiency and Blood Stasis Syndrome) by Yishen Huoxue Decoction

Objective:To observe the effect of Yishen Huoxue decoction on treating diabetic nephropathy Phase Ⅲ～Ⅴ(Qi-Yin Deficiency and Blood stasis Syndrome).Methods:45 cases were randomly divided into treatment groups(23 cases) and control groups(22 cases).Both groups were given basic medicine,while treatment group was given Yishen Huoxue decoction.Both groups were treated for 28 days.After treatment,the efficacy and clinical indexes were observed and compared.Results:There is remarkable difference at decreasing twenty-four-hour urine protein excretion in The treatment group,and both treatment group and comparison group have showed statistical significance in terms of reduction of HbA1c、Scr、BUN and heightened plasma albumine and eGFR.After treatment,the curative effect index changes of twenty-four-hour urine protein excretion、plasma albumine、Scr、BUN and eGFR showed a significant difference(P0.01) between treatment group and control group,while the changes of HbA1c have no significant difference(P0.05).Conclusion:Yishen Huoxue decoction on the basis of basic therapy can significantly improve the clinical effect of DN Ⅲ～Ⅴ,and alleviate the clinical symptoms,reduce proteinuria and serum creatinine、height eGFR and so on.It is worth to use in clinic on the basis of obviously clinical curative effect and safety.