Effect of spontaneous breathing trial in weaning of mechanical ventilation in patients with chronic obstructive pulmonary disease

Objective To assess the effect of spontaneous breathing trial(SBT) in the weaning process of mechanical ventilation of patients with chronic obstructive pulmonary disease(COPD).Methods 52 COPD patients were randomly divided into two groups.The S group(n=24) was extubated by the SBT method,and the NS group(n=28) was extubated by the method of decreasing mechanical ventilatory support level gradually.The duration of extubation and ICU stay,the incidence of ventilator-associated pneumonia(VAP) and reintubation rate within 48h,and hospital mortality were compared between the two groups.Results The time of extubation and ICU stay was 120 min and 9.5±4.2 days in the S group and 300.01±65.23 min and 18.6±10.3 days respectively in the NS group,and the incidence of VAP was 12.50% and 28.57% respectively in the S group and the NS group with significant difference(P0.05).The re-intubation rates were 20.83% and 21.43% and mortalities were 16.67% and 17.85% respectively in the S group and the NS group with no significant difference(P0.05).Conclusion SBT weaning method can greatly shorten the duration of extubation and ICU stay and lower the incidence of VAP while compared with the method of decrease of mechanical ventilation support level gradually.